Thio-substituted biaryl-methanesulfinyl derivatives

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 317/10 (2006.01) A61K 31/10 (2006.01) A61P 43/00 (2006.01) C07C 317/44 (2006.01) C07C 323/65 (2006.01) C07D 205/04 (2006.01) C07D 207/16 (2006.01) C07D 207/32 (2006.01) C07D 209/10 (2006.01) C07D 209/48 (2006.01) C07D 211/74 (2006.01) C07D 213/34 (2006.01) C07D 213/40 (2006.01) C07D 215/12 (2006.01) C07D 261/08 (2006.01)

Patent

CA 2561897

The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted biaryl- methanesulfinyl acetamides of Formula (I): wherein Ar, Y, R1, R2, R4, R5, q and x are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness associated with narcolepsy, obstructive sleep apnea, or shift work disorder; Parkinson's disease; Alzheimer's disease; attention deficit disorder; attention deficit hyperactivity disorder; depression; or fatigue associated with a neurological disease; as well as the promotion of wakefulness.

La présente invention concerne des compositions chimiques, leurs processus de préparation et des utilisations de la composition. Notamment, cette invention a trait à des compositions qui contiennent des acétamides de biaryl-méthanesulfinyle substitués de formule (I), dans laquelle Ar, Y, R?1¿, R?2¿, R?4¿, R?5¿, q et x sont tels que définis dans la description, et à leur utilisation dans le traitement de maladies, plus particulièrement, le traitement de la somnolence liée à la narcolepsie, à l'apnée obstructive ou au trouble du travail par roulement, le traitement de la maladie de Parkinson, de la maladie d'Alzheimer, du trouble déficitaire de l'attention, du trouble déficitaire de l'attention avec hyperactivité, de la dépression ou de la fatigue liée à une maladie neurologique, ainsi que dans l'encouragement de l'état de veille.

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