Thio-substituted tricyclic and bicyclic aromatic...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 405/12 (2006.01) A61K 31/4025 (2006.01) A61K 31/436 (2006.01) A61K 31/445 (2006.01) A61K 31/475 (2006.01) A61K 31/496 (2006.01) C07C 317/44 (2006.01) C07C 323/60 (2006.01) C07D 209/10 (2006.01) C07D 295/18 (2006.01) C07D 307/79 (2006.01) C07D 307/91 (2006.01) C07D 319/16 (2006.01) C07D 333/76 (2006.01)

Patent

CA 2562401

The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of compounds of Formula (A): wherein Ar, Y, R1 and q are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness, promotion of wakefulness, treatment of Parkinson~s disease, cerebral ischemia, stroke, sleep apneas, eating disorders, stimulation of appetite and weight gain, treatment of attention deficit hyperactivity disorder (~ADHD~), enhancing function in disorders associated with hypofunctionality of the cerebral cortex, including, but not limited to, depression, schizophrenia, fatigue, in particular, fatigue associated with neurologic disease, such as multiple sclerosis, chronic fatigue syndrome, and improvement of cognitive dysfunction.

L'invention concerne des compositions chimiques, des procédés de préparation de celles-ci et les utilisations de ces compositions. D'une manière plus spécifique, l'invention concerne des compositions de composés représentés par la formule (A): dans laquelle Ar, Y, R?1¿ et q sont définis dans le descriptif ; et leur utilisation dans le traitement de maladies, notamment le traitement de la somnolence, de la stimulation de l'éveil, de la maladie de Parkinson, de l'ischémie cérébrale, des accidents vasculaires cérébraux, de l'apnée du sommeil, des troubles de l'appétit, la stimulation de l'appétit et le traitement de la prise de poids, le traitement du trouble d'hyperactivité avec déficit de l'attention ( ADHD ), l'amélioration de la fonction dans des troubles associés à hypofonctionnalité du cortex cérébral, notamment, la dépression, la schizophrénie, la fatigue, en particulier, la fatigue associée à une maladie neurologique, telle que la sclérose en plaques, le syndrome de fatigue chronique et l'amélioration du dysfonctionnement cognitif.

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