Thioalkyl alpha substituted pyrimidine compounds

Details Thioalkyl alpha substituted pyrimidine compounds Thioalkyl alpha substituted pyrimidine compounds

C - Chemistry, Metallurgy

07

D

C07D 239/00 (2006.01) C07D 401/12 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2301800

The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula (I) and pyrimidine-thiolkyl and alkylethers of Formula (I), where R4 is selected from the group consisting of -H or -NR15R16 where R15 is -H and R16 is -H, C1-C6 alkyl, -NH2 or R15 and R16 taken together with the -N form 1- pyrrolidino, 1-morpholino or 1-piperidino; and R6 is -S-C1-6 alkyl (preferably -SCH3). The compounds of Formula (I) are useful in the treatment of individuals who are HIV positive.

L'invention concerne des composés à base de pyrimidinethioalkyl ou d'alkyléther qui correspondent à la formule suivante: (I) ainsi que pyrimidine thioalkyl et des alkyléthers qui correspondent à la formule (I), dans laquelle R¿4? est sélectionné dans un groupe constitué de -H ou de -NR¿15?R¿16? dans lequel R¿15? est H et R¿16? est -H, alkyle C¿1?-C¿6?, -NH¿2? ou R¿15? et R¿16? pris avec 1-pyrrolidino, 1-morpholino ou 1-pipéridino de forme -N; et R¿6? est -S-C¿1-6? alkyl (de préférence -SCH¿3?); les composés de la formule (I) sont utiles dans le traitement des personnes VIH séropositives.

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