Thioamide compounds or salts thereof and cytokine production...

Details Thioamide compounds or salts thereof and cytokine production... Thioamide compounds or salts thereof and cytokine production...

C - Chemistry, Metallurgy

07

C

C07C 327/48 (2006.01) A61K 31/166 (2006.01) A61K 31/275 (2006.01) A61K 31/325 (2006.01) A61K 31/41 (2006.01) A61K 31/4164 (2006.01) A61K 31/4192 (2006.01) A61K 31/426 (2006.01) A61K 31/428 (2006.01) A61K 31/44 (2006.01) A61K 31/4409 (2006.01) A61K 31/4412 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/4545 (2006.01) A61K 31/455 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61K 31/4965 (2006.01) A61K 31/505 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61P 3/10 (2006.01) A6

Patent

CA 2555624

The invention provides cytokine production inhibitors useful as preventive or therapeutic agents for diseases accompanied with abnormally enhanced immune function. Cytokine production inhibitors containing as the active ingredient thioamides represented by the general formula (I) or salts thereof: wherein A is N, NO, C-NO2, or C-CN; Hal is halogeno; M1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, a heterocycle, amino, O, S, SO, or SO2; M2 is amino, O, S, or a single bond; R1 is halogeno, alkyl, or the like; R2 R3, R4 and R5 are each independently H, alkyl, or the like; R6 is halogeno, alkyl, or the like; Cy is cycloalkyl, cycloalkenyl, aryl, or a heterocycle; k, p and q are each independently an integer of 0 to 3; and r is an integer of 0 to 5.

: L'invention fournit des inhibiteurs de production de cytokines utiles comme agents préventifs ou thérapeutiques pour des maladies accompagnées d'une fonction immunitaire anormalement accrue. Inhibiteurs de production de cytokines contenant comme ingrédient actif des thioamides représentés par la formule générale (I) ou des sels de ceux-ci : (I) dans laquelle A est N, NO, C-NO2 ou C-CN ; Hal est un halogéno; M<1> est un alkyle, un alcényle, un alcynyle, un cycloalkyle, un cycloalcényle, un aryle, un hétérocycle, un amino, O, S, SO ou SO2 ; M<2> est un amino, O, S ou une simple liaison ; R<1> est un halogéno, un alkyle ou similaire ; R<2> R<3>, R<4> et R<5> sont chacun indépendamment H, un alkyle ou similaire ; R<6> est un halogéno, un alkyle ou similaire ; Cy est un cycloalkyle, un cycloalcényle, un aryle ou un hétérocycle ; k, p et q sont chacun indépendamment un nombre entier valant 0 à 3 ; et r est un nombre entier valant 0 à 5.

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