Thioamide derivatives

Details Thioamide derivatives Thioamide derivatives

C - Chemistry, Metallurgy

07

C

C07C 327/46 (2006.01) A61K 31/165 (2006.01) A61K 31/4164 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) A61P 29/00 (2006.01) C07C 327/48 (2006.01) C07D 213/82 (2006.01) C07D 233/38 (2006.01) C07D 239/28 (2006.01) C07D 401/06 (2006.01)

Patent

CA 2362831

Compounds of formula (1): and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined in the specification, inhibit the binding of VCAM-1 to VLA-4 and are useful in treating inflammation associated with chronic inflammatory diseases such as rheumatoid arthritis (RA), multiple sclerosis (MS), asthma, and inflammatory bowel disease (I/BD).

L'invention se rapporte à des composés représentés par la formule (1) et à des sels et esters pharmaceutiquement acceptables de ces composés. Dans la formule (1), X et Y sont définis dans la description associée à l'invention. Ces composés inhibent la liaison de VCAM-1 à VLA-4 et ils s'avèrent utiles pour le traitement des inflammations associées à des maladies inflammatoires chroniques telles que la polyarthrite rhumatoïde (RA), la sclérose en plaques (MS), l'asthme et les affections intestinales inflammatoires (I/BD).

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