Thiocationic lipids, pharmaceutical compositions and methods...

Details Thiocationic lipids, pharmaceutical compositions and methods... Thiocationic lipids, pharmaceutical compositions and methods...

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) A61K 47/20 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07C 381/12 (2006.01) C07D 207/333 (2006.01) C07D 213/32 (2006.01) C07D 295/108 (2006.01) C07K 5/04 (2006.01) C12N 15/87 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2222586

Lipid molecules bearing a cationic charge are described. These cationic lipids are useful in the delivery of biomolecules, such as oligonucleotides, nucleic acids, peptides, diagnostic imaging agents, proteins and drug molecules. In the form of liposomes, they can effectively be used for the intracellular delivery of biomolecules for therapeutic or diagnostic purposes.

L'invention porte sur des molécules de lipides à charge cationique utiles pour libérer des biomolécules telles que des oligonucléotides, des acides nucléiques, des peptides, des agents de diagnostics par imagerie, des protéines et des molécules de médicaments. Sous la forme de liposomes, elles peuvent être utilisées efficacement pour assurer la libération intracellulaire de biomolécules à des fins thérapeutiques ou diagnostiques.

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