Thioether conjugates

Details Thioether conjugates Thioether conjugates

C - Chemistry, Metallurgy

07

H

C07H 15/252 (2006.01) A61K 47/48 (2006.01) C07D 519/04 (2006.01) C07H 15/26 (2006.01) C07H 19/04 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2087286

Provided are drug/ligand compounds of Formula (I): (see formula one) in which D is a drug moiety; n is an integer from 1 to 10; p is an integer from 1 to 6; Y is O or NH2+Cl-; z is 0 or 1; q is about 1 to about 10; X is a ligand; and, A is a Michael Addition Adduct. In a preferred embodiment, the ligand is an immunoglobulin, preferably a chimeric antibody or fragment thereof. Also provided are formulations comprising as an active ingredient a compound of Formula (I), intermediates useful for preparing the compounds of Formula (I), processes for preparing the compounds of Formula (I), and methods for using the compounds of the invention.

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