Thioether-substituted benzamides as inhibitors of factor xa

Details Thioether-substituted benzamides as inhibitors of factor xa Thioether-substituted benzamides as inhibitors of factor xa

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01)

Patent

CA 2541809

Thioether-substituted benzamide compounds having the formula: are provided that exhibit exceptionally strong inhibition of Factor Xa in combination with weak hERG binding.

L'invention a trait à des composés benzamides à substitution thioéther, qui sont représentés par la formule (I). Lesdits composés présentent une activité inhibitrice du facteur Xa exceptionnellement élevée, ainsi qu'une liaison à hERG faible.

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