Thioethylamide derivatives

C - Chemistry – Metallurgy – 07 – D

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260/361.1, 260/3

C07D 307/54 (2006.01) C07D 307/52 (2006.01) C07D 307/68 (2006.01) C07D 333/20 (2006.01) C07D 333/38 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01)

Patent

CA 1147337

ABSTRACT A compound of the formula: Image (wherein R is dimethylamino or l-pyrrolidinyl; R1 and R2 each is hydrogen or C1-C3 alkyl; R3 is hydrogen, C1-C3 alkyl (optionally substituted by one member selected from the group consisting of cyano, C1-C3 alkoxy, phenyl, and 5- or 6-membered heterocyclic group), C3-C6 cycloalkyl, C2-C5 alkenyl (optionally substituted by one member selected from the group consisting of C1-C3 alkoxy, phenyl, and phenoxy), C6-C10 aryl (optionally substituted by one or two members selec- ted from the group consisting of hydroxy, halogen, nitro, sulfa- moyl, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkanoyl, C2-C4 alkoxy- carbonyl, C2-C4 dialkylamino, and C1-C3 alkanesulfonyl), or 5- or 6-membered hetercyclic group (optionally substituted by one member selected from the group consisting of oxo, halogen, C1-C3 alkyl, and C1-C3 alkoxy); and X is oxygen or sulfur) and its pharmaceutically acceptable acid addition salts is use- ful as histamine H2 blockers.

366076

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