Thioformamide derivatives

Details Thioformamide derivatives Thioformamide derivatives

C - Chemistry, Metallurgy

07

D

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C07D 213/59 (2006.01) A61K 31/395 (2006.01) C07C 327/46 (2006.01) C07D 209/20 (2006.01) C07D 215/12 (2006.01) C07D 217/14 (2006.01) C07D 237/08 (2006.01) C07D 239/26 (2006.01) C07D 241/12 (2006.01) C07D 277/30 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2019106

- 42 - ABSTRACT A thioformamide derivative of the formula: Image I wherein R represents alkyl, A represents optionally substituted pyrid-3-yl, isoquinolin-4-yl, tetrahydroquinolin- 3-yl, quinolin-3-yl, pyridazin-4-yl, pyrimid-5-yl, thiazol-5- yl, thieno[2,3-b]pyridin-5-yl, pyrazin-2-yl, indol-3-yl, thieno[3,2-b]pyridin-6-yl, or phenyl and Y represents a valency bond, methylene or ethylene, R2 represents hydrogen, optionally substituted alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, aryloxyalkyl, aromatic heterocyclylalkyl or aromatic heterocyclyloxyalkyl group or a group BC(=O)- or BSO2 - in which B represents optionally substituted alkyl, aryl, or aromatic heterocyclic, n represents 0 or 1, and when n represents 0 R1 may represent a hydrogen atom, optionally substituted alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, aryloxyalkyl, aromatic heterocyclylalkyl or aromatic heterocyclyloxyalkyl group or a group BC(=O)-, and when n represents 1 R1 represents optionally substituted alkyl, - 43 - benzyl, phenethyl, 1-naphthylmethyl, 2-naphthylmethyl or pyrld-3-ylmethyl radical and pharmaceutically acceptable salts thereof possess pharmacological properties.

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