Thioglycerol derivatives

Details Thioglycerol derivatives Thioglycerol derivatives

C - Chemistry, Metallurgy

07

K

C07K 2/00 (2006.01) A61K 31/22 (2006.01) A61K 31/40 (2006.01) A61K 38/04 (2006.01) C07C 317/28 (2006.01) C07C 317/44 (2006.01) C07C 323/41 (2006.01) C07C 323/60 (2006.01) C07C 323/67 (2006.01) C07D 209/44 (2006.01) C07D 209/46 (2006.01) C07D 209/48 (2006.01) C07K 5/06 (2006.01) C07K 5/072 (2006.01) C07K 5/083 (2006.01) C07K 5/103 (2006.01) C07K 5/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2131639

Abstract of the Disclosure A compound represented by the formula: Image wherein R1 and R2 are the same or different, an acyl group; R3, R4, R6 and R7 are the same or different, hydrogen or an alkyl group; R5 is hydrogen, an alkyl group or a hydroxyl group which may optionally be protected, or R4 and R5 are combined to form a chemical bond; X is a carbonyl group or a sulfonyl group; Y is an amino acid sequence consisting of 1 to 7 amino acid residues which may optionally be protected and having optionally an intervening -SO2NH-; n is an integer of 0 to 2, or a salt thereof. The compound or salt thereof of the present invention possesses immunoenhancing activity and platelet reduction recovery activity, and can be used as a prophylactic/therapeutic agent for leukocytopenia in cancer chemotherapy or radiotherapy, as an immunoenhancing agent in bone marrow transplantation therapy and the treatment of osteomyelodysplasia and aplastic anemia, and as a prophylactic/therapeutic agent for thrombocytopenia.

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