Thiohydantoins and use thereof for treating diabetes

Details Thiohydantoins and use thereof for treating diabetes Thiohydantoins and use thereof for treating diabetes

C - Chemistry, Metallurgy

07

D

C07D 233/86 (2006.01) A61K 31/4166 (2006.01) A61P 3/10 (2006.01) C07D 221/00 (2006.01) C07D 317/00 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/10 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01) C07D 491/10 (2006.01)

Patent

CA 2444024

The invention concerns compounds derived from 2-thiohydantoin selected among compounds of general formula (I), such as defined in the claims, and their addition salts with an acid, in particular pharmaceutically acceptable salts. The invention also concerns the method for preparing same, pharmaceutical compositions containing them and their use as pharmacologically active substance, in particular for treating diabetes, diseases mediated by hyperglycemia, hypertriglyceridemiae, dyslipidaemiae or obesity.

L'invention concerne des composés dérivés de la 2-thiohydantoïne choisis parmi les composés de formule générale (I), telle que définie dans les revendications, et leurs sels d'addition avec un acide, notamment les sels pharmaceutiquement acceptables. Elle concerne également leur procédé de préparation, les compositions pharmaceutiques les contenant, et leur utilisation en tant que substance pharmacologiquement active, notamment dans le cas du traitement du diabète, des maladies dûes à une hyperglycémie, des hypertriglycéridémies, des dyslipidémies ou de l'obésité.

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