C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 323/20 (2006.01) A61K 31/70 (2006.01) A61P 3/06 (2006.01) A61P 29/00 (2006.01) C07C 323/60 (2006.01) C07H 15/203 (2006.01)
Patent
CA 2403823
Thioketals and thioethers are provided that inhibit the expression of VCAM-1, and which can be used in the treatment of VCAM-1 mediated diseases including inflammatory disorders, cardiovascular diseases, occular diseases, autoimmune diseases, neurological disorders, and cancer. The compounds also can be used to treat hyperlipidemia and/or hypercholesterolemia.
L'invention concerne des thiocétals et des thioéthers permettant d'inhiber l'expression de la molécule-1 d'adhésion cellulaire vasculaire (VCAM-1), et pouvant être utilisés pour traiter les maladies induites par la VCAM-1, y compris les troubles inflammatoires, les maladies cardio-vasculaires, les maladies oculaires, les maladies auto-immunes, les troubles neurologiques, et le cancer. En outre, ces composés peuvent être utilisés pour traiter l'hyperlipidémie et/ou l'hypercholestérolémie.
Hoong Lee K.
Meng Charles Q.
Sikorski James A.
Somers Patricia K.
Atherogenics Inc.
Mbm Intellectual Property Law Llp
LandOfFree
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