Thiol-based naaladase inhibitors

Details Thiol-based naaladase inhibitors Thiol-based naaladase inhibitors

C - Chemistry, Metallurgy

07

C

C07C 323/56 (2006.01) A61K 31/095 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C07C 323/52 (2006.01) C07C 323/58 (2006.01) C07C 323/59 (2006.01) C07C 323/60 (2006.01) C07C 323/62 (2006.01) C07C 323/65 (2006.01)

Patent

CA 2435273

This invention relates to thiol compounds of the formulae I, II or III (in which the variables are as defined in the claims), pharmaceutical compositions and diagnostic kits comprising such compounds and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF- .beta. activity, inhibiting angiogenesis, and treating glutamate abnormalities, diabetic neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.

Cette invention porte sur de nouveaux composés, sur des compositions pharmaceutiques et sur des kits de diagnostic comprenant ces composés, et sur des procédés d'utilisation de ces composés pour inhiber l'activité de l'enzyme NAALADase, détecter les maladies dans lesquelles les taux de NAALADase sont modifiés, rendre efficace l'activité neuronale ainsi que l'activité de TGF-b, inhiber l'angiogenèse et traiter les anomalies du glutamate, la neuropathie diabétique, la douleur, les troubles convulsifs, les maladies de la prostate, les cancers et le glaucome.

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