Thiol derivatives with metallopeptidase inhibitory activity

Details Thiol derivatives with metallopeptidase inhibitory activity Thiol derivatives with metallopeptidase inhibitory activity

C - Chemistry, Metallurgy

07

D

C07D 277/30 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) C07D 207/337 (2006.01) C07D 213/55 (2006.01) C07D 213/56 (2006.01) C07D 213/59 (2006.01) C07D 231/12 (2006.01) C07D 233/64 (2006.01) C07D 239/26 (2006.01) C07D 241/12 (2006.01) C07D 261/08 (2006.01) C07D 263/32 (2006.01) C07D 275/02 (2006.01) C07D 307/54 (2006.01) C07D 333/24 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/1

Patent

CA 2241414

Compounds of formula (I), wherein R, R1, R2, and R3 have the meanings reported in the description, processes for their preparation and pharmaceutical compositions which contain them as active ingredients are described. The compounds of formula (I) are endowed with a mixed ACE-inhibitory and NEP- inhibitory activity and are useful in the treatment of cardiovascular diseases.

Composés représentés par la formule (I) dans laquelle R, R¿1?, R¿2? et R¿3? possèdent la signification établie dans la description, procédés servant à les préparer et compositions pharmaceutiques les contenant en tant qu'ingrédients actifs. Ces composés possèdent une activité mixte d'inhibition d'ACE (enzyme de conversion d'angiotensine) et de NEP (endopeptidase neutre) et sont utiles dans le traitement de maladies cardio-vasculaires.

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