Thiol reactive liposomes

Details Thiol reactive liposomes Thiol reactive liposomes

A - Human Necessities

61

K

167/163, 167/37

A61K 9/50 (2006.01) A61K 9/127 (2006.01) A61K 39/44 (2006.01) B01J 13/02 (2006.01) G01N 33/532 (2006.01) G01N 33/563 (2006.01)

Patent

CA 1197190

THIOL REACTIVE LIPOSOMES Abstract of the Disclosure Liposomes are provided which have a plurality of thiol reactive groups extending outward of the liposomal bilayer. The liposomes form stable covalent bonds with ligands having thiol groups, such as Fab' fragments. Particularly preferred liposomes include maleimide moieties as the thiol reactive groups. The thiol reactive liposomes are usefully employed in agglutination assays, such as blood typing and binding inhibitions, and targeting to specific cells.

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