Thiol sulfonamide metalloprotease inhibitors

Details Thiol sulfonamide metalloprotease inhibitors Thiol sulfonamide metalloprotease inhibitors

C - Chemistry, Metallurgy

07

C

C07C 323/49 (2006.01) A61K 31/18 (2006.01) A61K 31/265 (2006.01) A61K 31/275 (2006.01) A61K 31/33 (2006.01) C07C 311/17 (2006.01) C07C 311/29 (2006.01) C07C 323/67 (2006.01) C07C 327/20 (2006.01) C07D 207/48 (2006.01) C07D 211/96 (2006.01) C07D 213/42 (2006.01) C07D 213/71 (2006.01) C07D 231/18 (2006.01) C07D 233/64 (2006.01) C07D 239/58 (2006.01) C07D 295/13 (2006.01) C07D 317/62 (2006.01) C07D 333/20 (2006.01) C07D 333/34 (2006.01) C07D 333/62 (2006.01) C07D 409/02 (2006.01) C07D 409/04 (2006.01)

Patent

CA 2260860

This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfonamide inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors, intermediates for the syntheses of proteinase inhibitors, processes for the preparation of proteinase inhibitors and processes for treating pathological conditions associated with phatological matrix metalloproteinase activity related to MMP- 13.

Cette invention se rapporte à des inhibiteurs de protéinases (protéases) et plus particulièrement à des inhibiteurs à base de sulfonamide de thiol pour les métalloprotéinases matricielles 13 (MMP-13), à des compositions d'inhibiteurs de protéinases, à des intermédiaires pour la synthèse de ces inhibiteurs de protéinases, à des procédés pour la préparation d'inhibiteurs de protéinases et à des procédés pour traiter des états pathologiques associés à une activité pathologique des métalloprotéinases matricielles de type MMP-13.

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