Thiols to promote hematopoietic progenitor cell growth

Details Thiols to promote hematopoietic progenitor cell growth Thiols to promote hematopoietic progenitor cell growth

A - Human Necessities

61

K

A61K 31/66 (2006.01) A61K 31/13 (2006.01) A61K 31/145 (2006.01)

Patent

CA 2213322

The present invention relates to methods of stimulating the growth of hematopoietic progenitor cells. In particular, it relates to the use of thiols and related compounds in stimulating the growth of hematopoietic progenitor cells in vitro and in vivo. Furthermore, the present invention relates to methods of using these compounds for the treatment of marrow failure states and immunodeficient conditions, including but not limited to myelodysplastic syndromes and acquired immunodeficiency syndrome. The figure discloses bone marrow colony formation assay.

La présente invention se rapporte à des procédés permettant de stimuler la croissance de cellules hématopoïétiques parentes. L'invention concerne plus particulièrement l'utilisation de thiols et de composés apparentés pour stimuler la croissance des cellules hématopoïétiques parentes in vitro et in vivo, ainsi que des procédés d'utilisation de ces composés pour le traitement d'insuffisances médullaires et d'états d'immunodéficience, notamment, mais non exclusivement, les syndromes myélodysplasiques et le syndrome de l'immunodéficience acquise. La figure représente le test de formation des colonies de la moelle osseuse.

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