Thionaphthalene derivative and preparation thereof and...

C - Chemistry – Metallurgy – 07 – C

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C07C 323/00 (2006.01) A61K 31/00 (2006.01) C07C 317/22 (2006.01) C07C 317/44 (2006.01) C07C 323/21 (2006.01) C07C 323/22 (2006.01) C07C 323/52 (2006.01) C07C 323/60 (2006.01) C07C 327/00 (2006.01) C07D 207/333 (2006.01) C07D 213/32 (2006.01) C07D 213/50 (2006.01) C07D 241/12 (2006.01) C07D 257/04 (2006.01) C07D 277/26 (2006.01) C07D 333/22 (2006.01) C07D 333/32 (2006.01)

Patent

CA 2030534

- 80 - ABSTRACT A thionaphthalene derivative having the following formula [I] or a non-toxic salt thereof: Image [I] wherein R represents a hydrogen atom, a substituted or unsubstituted C1 - C5 alkyl group, a substituted or unsubstituted aryl group, a heterocyclic group, a group -?-R4 (where R4 represents a substituted or unsubsti- tuted C1 - C5 alkyl group, a substituted or unsubsti- tuted aryl group or a heterocyclic group), a group -?-O-R5 (where R5 represents a hydrogen atom, a substi- tuted or unsubstituted C1 - C10 alkyl group, a substi- tuted or unsubstituted C3 - C10 alkenyl group or a substituted or unsubstituted C5 - C7 cycloalkyl group), a group -C-NH-R (where R6 represents a substituted or unsubstituted C1 - C5 alkyl group, a substituted or unsubstituted aryl group or a heterocyclic group) or cyano group, R1 and R2 each independently represent a hydrogen atom, a C1 - C5 alkyl group or phenyl group, R3 represents a hydrogen atom, a C1 - C5 alkyl group or -?-R7 (where R7 represents -OR81, -R82 or -NR832 , and R81, R82 and R83 each represent a C1 - C4 alkyl group, and n represents an integer of 0 to 2.

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