C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) A61K 31/70 (2006.01)
Patent
CA 2216284
Antisense oligonucleotides having improved cellular uptake, increased nuclease resistance, and thermodynamically more stable target-binding capacity are disclosed. These novel oligonucleotides are characterized by having from 1 to 10 thiono-triester phosphorothioate internucleoside linkages bearing lipophilic moieties.
Cette invention concerne des oligonucléotides anti-sens possédant des qualités d'absorption cellulaire accrues, une meilleure résistance à la nucléase, et des qualités de liaison à une cible plus stables sur le plan thermodynamique. Ces nouveaux oligonucléotides se caractérisent par le fait qu'ils possèdent de 1 à 10 liaisons d'internucléosides de phosphorothioate de thiono-triester ayant des moitiés lipophiles.
Tang Jimmy X.
Tang Jin Yan
Zhang Zhaoda
Hybridon Inc.
Mbm & Co.
LandOfFree
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