Thiopeptolide substrates for vertebrate collagenase

Details Thiopeptolide substrates for vertebrate collagenase Thiopeptolide substrates for vertebrate collagenase

C - Chemistry, Metallurgy

12

Q

530/7.06, 150/15

C12Q 1/37 (2006.01) C07K 7/02 (2006.01)

Patent

CA 1283500

NOVEL THIOPEPTOLIDE SUBSTRATES FOR VERTEBRATE COLLEGENASE ` Abstract of the Disclosure The disclosure relates to novel synthetic thiopeptolide substrates having high activity for the enzyme collagenase. These substrates have the following amino acid sequences: R-Pro-X-Gly-S-Y-Z-Gly-R1 wherein R = H or N-protecting group, X = Leu, Ile, Phe, Val, Gln, Ala, Y = Leu, Ile, Phe, Val, Ala, Z = Leu, Ile, Phe, Val, Gln, Ala, and R1= terminal amide, carboxyl or ester group.

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