(thiophen-2-yl)-piperidin or tetrahydropyridin...

Details (thiophen-2-yl)-piperidin or tetrahydropyridin... (thiophen-2-yl)-piperidin or tetrahydropyridin...

C - Chemistry, Metallurgy

07

D

C07D 451/02 (2006.01) A61K 31/46 (2006.01)

Patent

CA 2181759

This invention provides compounds having the structure Image wherein R is hydrogen, alkyl, alkenyl, alkynyl, -COR, phenyl, or phenylalkyl; the dotted line represents an optional double bond; R1 is hydrogen, -OH, OR3, or is absent if the optional double bond is present; R and R3 are each, independently alkyl, alkenyl, alkynyl, phenyl, or phenylalkyl; R4 is hydrogen, -OR5, alkyl, alkenyl, alkynyl, -COR5, -CO2R5, -CONR5R6, perhaloalkyl, halogen, phenyl, or phenylalkyl; R5 and R6 are each, independently, hydrogen, alkyl, alkenyl, alkynyl, phenyl, or phenylalkyl; and n = 0 - 2 or a pharmaceutically acceptable salt thereof that are useful as antipsychotic, antidepressant and anxiolytic agents useful in the treatment and relief of the symptoms of these disease states.

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