Thiophene 2-carboxamide derivatives and their pharmaceutical...

Details Thiophene 2-carboxamide derivatives and their pharmaceutical... Thiophene 2-carboxamide derivatives and their pharmaceutical...

C - Chemistry, Metallurgy

07

D

167/207, 260/270

C07D 409/12 (2006.01) A61K 31/33 (2006.01) C07D 333/38 (2006.01) C07D 409/14 (2006.01)

Patent

CA 1333176

Compounds of the following formula have pharmaceutical properties: Image in which R1 and R2 independently are hydrogen, halo, nitro, amino, C2-5 acylamino, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 alkylsulphonyl, N-substituted heterocyclyl, optionally substituted phenyl, optionally substituted phenylthio, optionally substituted phenylsulphonyl or optionally substituted phenylsulphonamido, or R1 and R2 together form a C3-5 alkylene bridge, R3 is C1-4 alkyl or C2-4 alkenyl, and X is (i) -(CH2)nN(R4)2 where each R4 independently is C1-4 alkyl, C2-4 alkenyl or optionally substituted C6H5CH2-, and n is 1, 2 or 3, or (ii) a 5- to 8-membered alicyclic group containing one or two nitrogen atoms and directly attached to the amido nitrogen or attached by a C1-3 alkylene chain; and salts thereof.

563471

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