Thiophene carboxamides as inhibitors of the enzyme ikk-2

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 333/38 (2006.01) A61K 31/4436 (2006.01) A61P 29/00 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2512336

The invention relates to thiophene carboxamides of formula (I) wherein Ar, R1, R2, R3, R4, R5, m and n are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

La présente invention concerne des thiophène carboxamides représentés par la formule (I), (dans cette formule, Ar, R?1¿, R?2¿, R?3¿, <SP>R4</SP>, R?5¿, m et n sont tels que définis dans la spécification. L'invention concerne également des procédés et des produits intermédiaires utilisés pour leur préparation. L'invention concerne également des compositions pharmaceutiques contenant ces thiophène carboxamides, ainsi que l'utilisation de ceux-ci à des fins thérapeutiques.

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