Thiophene derivatives

Details Thiophene derivatives Thiophene derivatives

C - Chemistry, Metallurgy

07

D

260/266.7, 260/2

C07D 409/06 (2006.01) C07D 295/04 (2006.01) C07D 333/06 (2006.01)

Patent

CA 1043792

This invention relates to compounds having the general formula (I) Image (I) and acid addition salts thereof in which formula R- is selected from the group consisting of A) ? mononuclear saturated or unsaturated heterocyclic group containing a sulphur atom, having 5 - 6 atoms in the ring system, B) substit- ution products of A) containing at least one substituent selected from the group consisting of halogen, nitro, alkoxy of 1 - 3 carbon atoms and alkyl groups having 1 - 6 carbon atoms. R2 is selected from the group consisting of C) an at least mononuclear, carbocyclic or heterocyclic group being saturated or unsaturated and having 5 - 10 atoms in the ring system, containing at least one oxygen, sulphur or nitrogen atom, D) substitution products of C) contain- ing at least one substituent selected from the group consisting of halogen, nitro-, trifluormethyl, alkyl having 1 - 6 carbon atoms, hydroxy, alkoxy having 1 - 3 carbon atoms, unsubstituted amino groups and amino groups substituted by up to two alkyl groups having 1 - 3 carbon atoms each, R3 is zero or up to two substituents being equal or different selected from alkyl groups having up to 2 carbon atoms and phenyl groups, X and Y being equal or different and are zero or selected from the group consisting of E) and alkyl group having 1-3 carbon atoms and F) substitution products of E) containing one substituent selected from the group consisting of alkyl groups each having 1 - 3 carbon atoms, a phenyl- and a thienyl group, A and B being equal or different and are zero or a methylene group with the provision that if X is zero, A is a methylene group and if Y is zero, B is a methylene group and n is 2 or 3, a process for its preparation and pharmaceutical composition containing said compound (I). The compounds of the invention possess psychotropic, analgesic and antiphlogistic activity.

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