Thiophenecarboxamide derivatives as ep4 receptor ligands

Details Thiophenecarboxamide derivatives as ep4 receptor ligands Thiophenecarboxamide derivatives as ep4 receptor ligands

C - Chemistry, Metallurgy

07

D

C07D 333/38 (2006.01) A61K 31/381 (2006.01) A61K 31/41 (2006.01) A61K 31/425 (2006.01) A61K 31/433 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) C07D 275/03 (2006.01) C07D 285/10 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2660133

The invention is directed to thiophenecarboxamide derivatives of formulae I and II as EP4 receptor ligands, antagonists or agonists, useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoid arthritis, cancer and glaucoma. Pharmaceutical compositions and methods of use are also included. (Formulas I and II).

La présente invention concerne des dérivés de thiophènecarboxamide répondant aux formules I et II en tant que ligands du récepteur EP4 ou d'agonistes, se révélant utiles pour le traitement de maladies ou d'affections médiées par le récepteur EP4, telles qu'une douleur aiguë et chronique, une ostéoarthrite, une polyarthrite rhumatoïde, un cancer et un glaucome. L'invention concerne également des compositions pharmaceutiques et des procédés d'utilisation.

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