C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/55 (2006.01)
Patent
CA 2636992
The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention, are thiophenyl and pyrrolyl azepine compounds. These compounds are serotonin receptor (5- HT2c) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT20) is desired (e.g. addiction, anxiety, depression, obesity, and others).
La présente invention concerne généralement une série de composés, des compositions pharmaceutiques contenant ces composés et l~utilisation de ces composés et compositions comme agents thérapeutiques. Plus spécifiquement parlant, les composés de la présente invention sont des composés d~azépine de thiophényle et pyrrolyle. Ces composés sont des ligands de récepteurs de sérotonine (5- HT2c) utiles dans le traitement de maladies, troubles et conditions où la modulation de l~activité des récepteurs de sérotonine (5-HT20) est souhaitée (p. ex. la dépendance aux substances illicites, l~anxiété, la dépression, l~obésité et autres).
Bennani Youssef L.
Bom David C.
Robarge Michael J.
Tumey L. Nathan
Athersys Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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