C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 409/04 (2006.01) A61K 31/38 (2006.01) A61P 17/00 (2006.01) A61P 19/00 (2006.01) A61P 35/00 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07F 7/08 (2006.01)
Patent
CA 2459882
A compound of the formula : in which R1 is optionally substituted phenyl, optionally substituted naphthyl, optionally substituted bicyclic heterocyclic group, optionally substituted lower alkenyl or optionally substituted lower alkynyl, and R2 is carboxy or protected carboxy, or a salt thereof, useful for treating and/or preventing MMP- or TNF-.alpha. mediated diseases.
L'invention porte sur un composé de formule (I) dans laquelle: R?1¿ est phényle facultativement substitué, naphthyle facultativement substitué, un groupe bicyclique hétérocyclique facultativement substitué, un alcényle inférieur facultativement substitué ou un alkynyle facultativement substitué, et R?2¿ est carboxy ou carboxy protégé, ou l'un de ses sels. Ledit composé s'avère utile pour traiter et/ou prévenir les maladies médiées par le MMP- ou le TNF-.alpha..
Abe Yoshito
Inoue Makoto
Ishibashi Naoki
Mizutani Tsuyoshi
Neya Masahiro
Fujisawa Pharmaceutical Co. Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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