G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/53 (2006.01)
Patent
CA 2595407
The present invention relates to screening assays for the identification of agents that can modify the interaction of thioredoxin interacting protein (TXNEP) on thioredoxin (TRX)5 preferably by inhibiting TXNIP downregulation of TXR. The use of such compounds, including the disclosed siRNA and antibodies against TXNIP, is contemplated for therapeutic or prophylactic treatment of vascular disease conditions, particularly those associated with pro- inflammatory activity of the TNF- ASKl-JNK-p38 pathways.
La présente invention a trait à des dosages de criblage pour l'identification d'agents pouvant modifier l'interaction de la protéine d'interaction avec la thiorédoxine (TXNIP) sur la thiorédoxine (TRX) de préférence par l'inhibition de la régulation négative de TXR. L'utilisation de tels composés, comprenant les ARNsi et anticorps de l'invention contre la TXNIP, est envisagée pour le traitement thérapeutique ou prophylactique des conditions de maladie vasculaire, notamment celles associées à l'activité pro-inflammatoire des voies p38 de la protéine kinase 1 régulatrice de signal d'apoptose du facteur de nécrose tumorale (TNF- ASKl-JNK-p38).
Gowling Lafleur Henderson Llp
University Of Rochester
LandOfFree
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