C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/337 (2006.01) A61K 31/436 (2006.01) A61K 31/496 (2006.01) A61K 31/517 (2006.01) A61K 31/704 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 471/14 (2006.01)
Patent
CA 2730890
A synergistically effective combination of an anti-cancer agent and a thiosemicarbazone therapeutic compound of formula (I), which is an mTOR-Rictor inhibitor, a Serine 473 phosphorylation inhibitor, an AKT2 inhibitor, or a combination thereof, for use in the treatment of cancer, and methods and uses thereof. Also included are methods and uses of a thiosemicarbazone for treating a cancer in a mammal in need thereof, characterized by over- expression of RAS, by an EGFR mutation, and/or by over-expression of AKT2.
La présente invention concerne une combinaison synergique efficace dun agent anticancéreux et dun composé thérapeutique, tel quun inhibiteur du complexe mTOR-Rictor, un inhibiteur de phosphorylation de sérine 473, un inhibiteur de AKT2, ou une combinaison de ceux-ci, pour utilisation dans le traitement du cancer et des procédés et utilisations de celle-ci. La présente invention concerne en outre des procédés et utilisations dune thiosemicarbazone pour le traitement dun cancer chez un mammifère en ayant besoin caractérisé par une surexpression de RAS, par une mutation de EGFR, et/ou par une surexpression de AKT2.
Critical Outcome Technologies Inc.
Sim & Mcburney
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