Thiouracil derivatives, pharmaceutical compositions...

C - Chemistry – Metallurgy – 07 – D

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C07D 239/56 (2006.01) A61K 31/505 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2013916

ABSTRACT OF THE DISCLOSURE The present invention relates to novel compounds of the general formula (I), Image (I) wherein R1 and R2 stand independently from each other, for hydrogen, C1-4alkyl, phenyl, phenyl-C1-4alkyl, piridyl or piridyl-C1-4alkyl group; E means a straight or branched, saturated hydrocarbon chain containing 1 to 6 carbon atoms; R3 represents: a phenyl group ortho-substituted by a C2- 5alkanoylamino, N-C2-5alkanoyl-N-C1-4alkylamino or di(C1- 4alkyl)amino group and optionally further substituted by halogen, C1-4alkyl, C1-4alkoxy or C2-5alkanoyloxy group; or a pyridyl group optionally mono- or polysubstituted by halogen, C1-4alkyl, C1-4alkoxy, C2-5alkanoyloxy or phenyl-C1-4alkoxy group.

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