C - Chemistry – Metallurgy – 07 – B
Patent
C - Chemistry, Metallurgy
07
B
C07B 61/00 (2006.01) A61K 31/00 (2006.01) A61P 35/02 (2006.01) C07C 275/24 (2006.01) C07C 335/12 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2367857
This invention provides combinatorial chemistry libraries containing thiourea and urea compounds of formula (I), in which X is S or O; R and R~1? are individually (CHR) -Ar; and the other variables are as defined in the claims. In addition, the invention relates to methods for construction combinatorial chemistry libraries containing thiourea and urea compounds. Furthermore, this invention relates to methods for the identification of bioactive thiourea and urea compounds as well as compositions and therapeutic methods for treating cancer.
L'invention concerne des banques de chimie combinatoire contenant des compos~s de thio-ur~e et d'ur~e de la formule I. X repr~sente S ou O; R et R´1? repr~sentent individuellement (CHR) Ar, les autres variables ~tant telles que d~finies dans les revendications. En outre, l'invention concerne des proc~d~s de construction de banques de chimie combinatoire contenant des compos~s de thio-ur~e et d'ur~e, ainsi que des proc~d~s d'identification de compos~s bioactifs de thio-ur~e et d'ur~e et des compositions et proc~d~s th~rapeutiques pour traiter le cancer.
Mao Chen
Narla Rama K.
Uckun Fatih M.
Zhu Zhaohai
Goudreau Gage Dubuc
Parker Hughes Institute
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