Thiourea inhibitors of herpes viruses

Details Thiourea inhibitors of herpes viruses Thiourea inhibitors of herpes viruses

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/33 (2006.01) A61P 31/12 (2006.01) C07D 207/32 (2006.01) C07D 207/335 (2006.01) C07D 209/14 (2006.01) C07D 213/40 (2006.01) C07D 213/75 (2006.01) C07D 215/12 (2006.01) C07D 217/12 (2006.01) C07D 231/56 (2006.01) C07D 233/44 (2006.01) C07D 277/28 (2006.01) C07D 285/06 (2006.01) C07D 307/52 (2006.01) C07D 333/20 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2350996

Compounds of formula (I) wherein A is heteroaryl; R9-R12 are independently hydrogen, alkyl of 1 to 4 carbon atoms, perhaloalkyl of 1 to 4 carbon atoms, halogen, alkoxy of 1 to 4 carbon atoms, or cyano, or R9 and R10 or R11 and R12 may be taken together to form aryl of 5 to 7 carbon atoms; W is O, NR6, or is absent; G is aryl or heteroaryl; and X is a bond, -NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; and J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; or a pharmaceutical salt thereof, useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.

La présente invention concerne des composés représentés par la formule générale (I) ou l'un de ses sels pharmaceutiques. Dans cette formule, A est hétéroaryle; R¿9?-R¿12? sont indépendamment hydrogène, C¿1?-C¿4? alkyle, C¿1?-C¿4? perhaloalkyle, halogène, C¿1?-C¿4? alcoxy, ou cyano, ou R¿9? pris avec R¿10? ou R¿11? pris avec R¿12? peuvent former un C¿5?-C¿7? aryle; W est O, NR¿6?, ou est absent; G est aryle ou hétéroaryle; et X est une liaison, -NH, C¿1?-C¿6? alkyle, C¿1?-C¿6? alcényle, C¿1?-C¿6? alcoxy, C¿1?-C¿6? thioalkyle, C¿1?-C¿6? alkylamino, ou (CH)J; et J est C¿1?-C¿6? alkyle, C¿3?-C¿7? cycloalkyle, phényle ou benzyle; et n est un entier de 1 à 6. Ces composés conviennent au traitement d'affections associées au virus de l'herpès, y-compris le cytomégalovirus humain, les herpèsvirus simplex, le virus d'Epstein-Barr, le virus de la varicelle-zona, les herpèsvirus -6 et -7 humains, et l'herpèsvirus de Kaposi.

Affiliated with

Also associated with

Rating

Thiourea inhibitors of herpes viruses does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Thiourea inhibitors of herpes viruses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thiourea inhibitors of herpes viruses will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1792670