Thioxanthenone antitumor agents

Details Thioxanthenone antitumor agents Thioxanthenone antitumor agents

C - Chemistry, Metallurgy

07

D

C07D 335/16 (2006.01) A61K 31/38 (2006.01) A61K 31/67 (2006.01) C07F 9/547 (2006.01) C07F 9/6553 (2006.01)

Patent

CA 2120782

1-[[Dialkylamino)alkyl]amino]-4-substituted-thioxanthen- 9-ones of the formula: Image (wherein n is 2 or 3, R1 and R2 are alkyl, Q is CH2NHR3, CH2N(R4)SO2R7, CH2NHCHO, CH=N-Ar, CONR5R6, CH2NR4COR7, CH2N(C2H5)CHO, CH2NR4P(0)(0-alkyl)2, CH2N=CH-NR9R10, CH2NR4COCF3 or CH2NR4COOR7, R3 is H or alkyl, R4 is H, alkyl or Ar, R5 is H, alkyl or Ar, R6 is H or alkyl, R7 is alkyl or Ar, R8 is OH, H, alkyl or alkoxy, Ar is optionally substituted phenyl, and R9 and R10 are alkyl) are disclosed as antitumor agents. Compositions containing the thioxanthenones and methods of treating tumors and cancer in mammals with the thioxanthenones are also disclosed.

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