C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 473/22 (2006.01) A61K 31/522 (2006.01) A61P 9/10 (2006.01) A61P 11/08 (2006.01) A61P 25/16 (2006.01) A61K 31/52 (2006.01) C07D 473/20 (2006.01)
Patent
CA 2649150
There are disclosed novel compounds of Formula (I) wherein L, R1, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme MPO and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders, cardio- and cerebrovascular atherosclerotic disorders and peripheral artery disease and respiratory disorders.
L'invention concerne de nouveaux composés représentés par la formule I, dans laquelle L, R1, X et Y sont tels que définis dans le descriptif, et les sels pharmaceutiquement acceptables de ces composés; des procédés de préparation de ces composés, des compositions les contenant et l'utilisation thérapeutique de ceux-ci. Ces composés constituent des inhibiteurs de l'enzyme MPO et sont par conséquent particulièrement utiles pour traiter ou prévenir des troubles neuro-inflammatoires, des troubles athéroscléreux cardiovasculaires et cérébrovasculaires, la maladie artérielle périphérique et des troubles respiratoires.
Tiden Anna-Karin
Viklund Jenny
Astrazeneca Ab
Mccarthy Tetrault Llp
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