Thioxanthine derivatives as myeloperoxidase inhibitors

Details Thioxanthine derivatives as myeloperoxidase inhibitors Thioxanthine derivatives as myeloperoxidase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 473/36 (2006.01) A61K 31/52 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2480452

There is disclosed the use of a compound of formula (Ia) or (Ib)wherein R1, R2, R3, R4, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof, in the manufacture of a medicament, for the treatment or prophylaxis of diseases or conditions in which inhibition of the enzyme myeloperoxidase (MPO) is beneficial. Certain novel compounds of formula (Ia) or (Ib) and pharmaceutically acceptable salts thereof are disclosed, together with processes for their preparation. The compounds of formulae (Ia) and (Ib) are MPO inhibitors and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders.

L'invention concerne l'utilisation d'un composé de formule (Ia) ou (Ib), dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, X et Y ont la signification indiquée dans la description, et de ses sels pharmaceutiquement acceptables, pour la fabrication d'un médicament servant au traitement ou à la prophylaxie de maladies ou d'états dans lesquels l'inhibition de la myéloperoxydase (MPO) présente un effet bénéfique. L'invention concerne certains nouveaux composés de formule (Ia) ou (Ib) et leurs sels pharmaceutiquement acceptables, ainsi que des procédés pour leur préparation. Lesdits composés représentés par les formules (Ia) et (Ib) constituent des inhibiteurs de la MPO et sont par conséquent particulièrement utiles pour le traitement ou la prophylaxie de troubles neuro-inflammatoires.

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