Thixotropic pharmaceutical compositions

Details Thixotropic pharmaceutical compositions Thixotropic pharmaceutical compositions

A - Human Necessities

61

K

A61K 9/00 (2006.01)

Patent

CA 2678480

The present invention relates to a thixotropic pharmaceutical composition in which the viscosity is changed due to external mechanical stress applied so that isothermal and continuous gel/sol/gel transition occurs. The thixotropic pharmaceutical composition includes a pharmacologically active substance, a biocompatible thickener having a predetermined thixotropic property, and optionally a hydrophilic thickener. The viscosity of the composition is relatively rapidly changed within a predetermined range. Accordingly, it is easy to measure the amount of drugs to be administered, it is possible to administer a precise amount of drugs to a patient, the compliance of a patient with dosage of drugs is high, and it is easy to produce the composition.

La présente invention concerne une composition pharmaceutique thixotrope dont la viscosité est modifiée sous l'action d'une contrainte mécanique extérieure appliquée, de sorte qu'une transition gel/sol/gel isothermique et continue se produise. Cette composition pharmaceutique thixotrope comprend une substance pharmacologiquement active, un épaississant biocompatible présentant une propriété thixotrope prédéterminée, et éventuellement un épaississant hydrophile. La viscosité de la composition est modifiée relativement rapidement dans une plage prédéterminée. Par conséquent, l'invention permet de mesurer facilement la dose médicamenteuse à administrer, d'administrer une dose médicamenteuse précise à un patient, d'obtenir une haute observance du dosage médicamenteux par le patient, et de produire facilement ladite composition.

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