Three component chimeric antisense oligonucleotides

Details Three component chimeric antisense oligonucleotides Three component chimeric antisense oligonucleotides

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2266748

The present application describes a novel family of oligonucleotide compounds having a novel organization of various modified nucleotides and modified chemical linkages. The application further discloses that limiting the presence and extent of specific modified nucleotides/modified linkages in the oligomers results in enhanced activation of endogenous RNase H activity.

Dans la présente invention est décrite une nouvelle famille de composés oligonucléotidiques dotés d'une nouvelle organisation de divers nucléotides modifiés et liaisons chimiques modifiées. Cette invention porte en outre sur la découverte qu'une limitation de la présence et de l'étendue de nucléotides modifiés/liaisons modifiées spécifiques dans les oligomères a pour résultat une activation améliorée de l'activité de la RNase H endogène.

Affiliated with

Also associated with

Rating

Three component chimeric antisense oligonucleotides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Three component chimeric antisense oligonucleotides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Three component chimeric antisense oligonucleotides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1397680