C - Chemistry – Metallurgy – 12 – M
Patent
C - Chemistry, Metallurgy
12
M
C12M 1/34 (2006.01) C12M 3/00 (2006.01) C12N 5/00 (2006.01) C12N 5/02 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2524496
The present invention provides a novel microscale fluid handling system for initiating, culturing, manipulating and assaying three-dimensional multicellular assembly. The system including a microfluidic device and three- dimensional multicellular tissue surrogate assembly. The device of the invention includes at least one microfluidic channel; and at least one chamber, wherein the walls of the chamber are lined with a cell layer; and wherein fluid medium flows through each of the channels and chambers. Also, disclosed are methods for using the device to introducing test agents to the multicellular assemblies to observe biological responses thereof.
L'invention concerne un nouveau système de manipulation fluidique à petite échelle pour amorcer, cultiver, manipuler et doser un ensemble multicellulaire tridimensionnel. Ledit système comporte un dispositif microfluidique et un ensemble substitut de tissu multicellulaire tridimensionnel. Ledit dispositif comporte au moins un canal microfluidique ; et au moins une chambre, dont les parois sont garnies d'une couche cellulaire ; le milieu fluidique traversant chacun des canaux et des chambres. L'invention concerne en outre des procédés d'utilisation du dispositif pour présenter des agents d'essai aux ensembles multicellulaires afin d'observer leurs réactions biologiques.
Beebe David J.
Lowery Robert G.
Majer John
Bellbrook Labs Llc
Gowling Lafleur Henderson Llp
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