C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2385851
The present invention provides methods for detecting nucleic acid mutations and genetic polymorphisms by single base extension analysis. Specifically, the invention provides an apparatus and methods for the detection of single base extension of a particular oligonucleotide in an oligonucleotide microarray following hybridization between oligonucleotides bound to defined regions of a polymeric hydrogel-based microarray and nucleic acids in a biological sample.
L'invention porte sur des méthodes de détection des mutations d'acide nucléique et de polymorphismes génétiques par analyse de l'extension d'une base isolée, et spécifiquement sur un appareil et des procédés de détection de l'extension d'une base isolée d'un oligonucléotide particulier d'un micro-réseau d'oligonucléotides suite à une hybridation entre des oligonucléotides fixés à des régions définies d'un micro-réseau polymérique à base d'hydrogel et aux acides nucléiques d'un échantillon biologique.
Ge Healthcare Bio-Sciences Ab
Motorola Inc.
Smart & Biggar
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