C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/90 (2006.01) A61K 45/00 (2006.01) A61P 3/04 (2006.01) A61P 25/00 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C30B 29/58 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2466264
It is intended to provide a method of designing an antiallergic agent, a sleep controlling agent, an antiobestic and a remedy for brain injury acting via the inhibition of the biosynthesis of prostaglandin D2. Crystals of a complex of human-origin hematopoietic prostaglandin D synthase, glutathione and a substrate analog or an inhibitor, etc. are prepared and the three-dimensional structural coordinate of each atom in the complex is determined by X-ray crystal analysis.
L'invention concerne un procédé permettant de concevoir un agent anti-allergique, un agent de régulation du sommeil, un agent contre l'obésité et un médicament pour les lésions cérébrales via l'inhibition de la biosynthèse de la prostaglandine D2. On prépare des cristaux de complexe de prostaglandine synthase D hématopoïétique d'origine humaine et de glutathione, et un analogue de substrat ou un inhibiteur, etc., et on détermine les cordonnées structurelles de chaque atome dudit complexe par analyse des cristaux aux rayons X.
Hayaishi Osamu
Inoue Tsuyoshi
Irikura Daisuke
Kai Yasushi
Kinugasa Shigehiro
Japan Science And Technology Agency
Kirby Eades Gale Baker
Osaka Bioscience Institute
Riken
LandOfFree
Three-dimensional structure of prostaglandin d synthase and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Three-dimensional structure of prostaglandin d synthase and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Three-dimensional structure of prostaglandin d synthase and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1807449