C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/735 (2006.01) A61K 38/17 (2006.01) G06T 15/00 (2006.01) G06T 17/40 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2316860
Disclosed are crystals, crystal structure Fc.gamma.RIIa protein, three- dimensional coordinates of Fc.gamma.RIIa protein, and structures and models derived from the Fc.gamma.RIIa structure. Also disclosed are crystals of Fc.epsilon.RI protein and three-dimensional coordinates of Fc.epsilon.RI protein monomers and dimers derived from the Fc.gamma.RIIa structure. Also disclosed are three-dimensional coordinates of Fc.gamma.RIIIb proteins and models of Fc.gamma.RIIIb derived from the Fc.gamma.RIIa structure. The present invention also includes methods to produce such crystals, crystal structures and models. Uses of such crystals, crystal structures and models are also disclosed, including structure based drug design and therapeutic compositions.
L'invention concerne des cristaux, une protéine Fc.gamma.RIIa à structure cristalline, les coordonnées tridimensionnelles de la protéine Fc.gamma.RIIa, et des structures et des modèles dérivés de la structure de Fc.gamma.RIIa. L'invention concerne également des cristaux de protéine Fc.epsilon.RI et les coordonnées tridimensionnelles de monomères et de dimères protéiniques Fc.epsilon.RI dérivés de la structure Fc.gamma.RIIa, ainsi que les coordonnées tridimensionnelles de protéines Fc.gamma.RIIIb et des modèles de Fc.gamma.RIIIb dérivés de la structure de Fc.gamma.RIIa. La présente invention concerne enfin des méthodes permettant de produire ces cristaux et structures et modèles de cristaux, ainsi que les utilisations de ces cristaux, et structures et modèles de cristaux, notamment dans la mise au point de médicaments et de compositions thérapeutiques basés sur ces structures.
Epa Vidana
Garrett Thomas P. J.
Hogarth P. Mark
Maxwell Kelly F.
Mckenzie Ian F. C.
Ilexus Pty. Limited
Sim & Mcburney
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