C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C30B 29/58 (2006.01) G01N 23/20 (2006.01) G01N 33/566 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2465268
Disclosed are TALL-1 and TALL-1 receptor protein homologues (agonists and antagonists) designed based on the three-dimensional structure of sTALL-1, eBCMA and eBAFF-R; agonist homologues of APRIL; methods of using wild-type APRIL to inhibit the activity of TALL-1; compositions comprising such homologues, nucleic acid molecules encoding such homologues, and therapeutic methods of using such compounds and compositions. Also disclosed are crystalline complexes of sTALL-1 and sTALL-1 in complex with either BCMA or BAFF-R; models of three-dimensional structures of such crystalline complexes and related structures, methods of drug design using any portion of such structures; methods of design and/or identification of regulatory peptides derived from the such structures; compounds identified by drug design using such structures; and the use of such compounds in therapeutic compositions and methods.
L'invention concerne des homologues de protéine de récepteur TALL-1 et TALL-1 (agonistes et antagonistes) conçus sur la base de la structure tridimensionnelle de sTALL-1, d'eBCMA et de eBAFF-R, des homologues agonistes d'APRIL, des procédés d'utilisations d'APRIL de type sauvage afin d'inhiber l'activité de TALL-1, des compositions comprenant de tels homologues, des molécules d'acides nucléiques codant pour ces homologues et des méthodes de soins utilisant ces composés et ces compositions. L'invention concerne aussi des complexes cristallins de sTALL-1 et de sTALL-1 complexé avec BCMA ou avec BAFF-R, des modèles de structures tridimensionnelles de tels complexes cristallins et des structures associées, des procédés de conception de médicament utilisant une partie quelconque de ces structures, des procédés de conception et/ou d'identification de peptides régulateurs dérivés de ces structures, des composés identifiés grâce à la conception de médicament utilisant de ces structures, et l'utilisation de ces composés dans des méthodes et des compositions de soins.
Liu Yingfang
Shu Hong-Bing
Xu Liangguo
Zhang Gongyi
National Jewish Medical And Research Center
Sim & Mcburney
LandOfFree
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