Three-layer parenteral preparations

Details Three-layer parenteral preparations Three-layer parenteral preparations

A - Human Necessities

61

K

A61K 9/50 (2006.01) A01N 25/28 (2006.01) A01N 37/18 (2006.01) A61K 8/02 (2006.01) A61K 8/73 (2006.01) A61K 8/81 (2006.01) A61K 31/00 (2006.01) A61K 31/165 (2006.01) A61K 35/39 (2006.01) A61K 35/74 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 38/23 (2006.01) A61K 38/27 (2006.01) A61K 38/28 (2006.01) A61K 47/32 (2006.01) A61K 47/34 (2006.01) A61K 47/38 (2006.01) A61Q 5/10 (2006.01) A61Q 17/02 (2006.01) C09B 67/02 (2006.01) C09B 67/08 (2006.01) C11B 9/00 (2006.01)

Patent

CA 2410293

A function other than sustained release, i.e., targetability or adhesion, is imparted to micro- or milli-capsules and a film, and a target substance to be encapsulated or embedded is encapsulated or embedded at approximately 100% efficiency. The nonoral preparation is characterized by having a three-layer structure which is composed of a base layer made of a polymer, a retention layer for holding a target substance selected among a drug, perfume, mosquitoe repellent, pigment, cell, and antigen, and a surface layer and in which the retention layer is interposed between the base layer and the surface layer.

On confère, dans le cadre de cette invention, à des capsules ou à un film, de l'ordre du micromètre ou du millimètre, une fonction autre que celle de libération lente. On y encapsule ou on y incorpore une substance cible avec environ 100 % de réussite. Cette préparation, administrable autrement que par la voie orale, se caractérise par le fait qu'elle est constituée de trois couches, en l'occurrence, d'une couche de base à base de polymère, d'une couche de retenue conservant la substance cible, notamment un médicament, un parfum, un anti-moustique, un pigment, une cellule ou un antigène, et d'une couche de protection, la couche de retenue venant s'interposer entre la couche de base et la couche de protection.

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