Three polyumorphic forms of 5-[3-(2,2,2-...

Details Three polyumorphic forms of 5-[3-(2,2,2-... Three polyumorphic forms of 5-[3-(2,2,2-...

C - Chemistry, Metallurgy

07

D

260/315.3

C07D 231/40 (2006.01)

Patent

CA 1198734

ABSTRACT OF THE DISCLOSURE This invention relates to three polymorphic forms of 5-[3-(2-[2,2,2-trifluoroethyl]quanidino)-pyrazol-1-yl]valeramide, two of which are practically crystallographically pure, and to processes for their manufacture. Polymorph A, having a crystallographic purity of at least 90%, is characterised by an attenuated total reflection (ATR) infra-red spectrum having bands at 1685 (ms), 1560 (w), 1540 (m), 1455 (w), 1060 (mw), 832 (m), 788 (w) and 365 (m) cm-1. Polymorph B, having a crystallo- graphic purity of at least 90%, is characterised by an attenuated total reflection (ATR) infra-red spectrum having bands at 1665 (ms), 1550 (s), 1445 (m), 1360 (w), 1215 (mw), 1070 (w), 1050 (mw), 990 (w), 935 (w), 822 (m), 380 (m) and 350 (mw) cm-1. These polymorphs can be prepared by specific crystallisation processes.

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