Threonine derived asymmetric chemical synthesis and...

Details Threonine derived asymmetric chemical synthesis and... Threonine derived asymmetric chemical synthesis and...

C - Chemistry, Metallurgy

07

D

C07D 319/06 (2006.01) C07C 33/46 (2006.01) C07C 69/78 (2006.01) C07C 315/02 (2006.01) C07C 317/16 (2006.01) C07D 233/60 (2006.01) C07D 249/08 (2006.01) C07D 405/02 (2006.01) C07D 407/02 (2006.01) C07D 407/12 (2006.01) C07D 409/02 (2006.01) C07D 413/02 (2006.01) C07D 417/02 (2006.01) C07D 473/00 (2006.01) C07D 493/10 (2006.01) C07D 495/10 (2006.01) C07D 521/00 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2065259

2065259 9103473 PCTABS00003 Intermediates of structural formula (III) or (Va) having an asymmetric center as indicated by an asterisk (*) and being substantially free of its opposite enantiomeric form, wherein Z represents O or NOP1; P1 is (a), (b), (c), H, alkyl, benzyl, substituted benzyl, alkoxy-substituted phenyl, alkyloxyalkyl, alkylthioalkyl or R'R''R''' silyl, R1 and R2 may be the same or different and each independently represents H, alkyl, phenyl, substituted phenyl or R1 and R2 together with the carbon to which they are attached represent the group (d), Y is O, S(O)p or (CRaRb); and processes for making chemically pure, enantiomeric antifungal compounds using a threonine derived asymmetric chemical synthesis.

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