Thrombin activatable plasminogen derivatives

Details Thrombin activatable plasminogen derivatives Thrombin activatable plasminogen derivatives

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 38/48 (2006.01) C12N 1/19 (2006.01) C12N 5/10 (2006.01) C12N 9/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2145749

A plasminogen analogue activatable by thrombin to have plasmin activity which contains the cleavage site sequence P4-P3-Pro-Arg-P1'-P2' where P3 is a basic amino acid residue, P4 is a hydrophobic amino acid residue and each of P1' and P2' is independently a non-acidic amino acid residue, said site being cleavable by thrombin between Arg and P1'.

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