Thrombin-cleavable factor x analogues

Details Thrombin-cleavable factor x analogues Thrombin-cleavable factor x analogues

C - Chemistry, Metallurgy

07

K

C07K 14/745 (2006.01) A61K 38/36 (2006.01) A61K 48/00 (2006.01) A61P 7/04 (2006.01) C12N 9/64 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2491040

The invention relates to factor X analogues containing the thrombin-cleavable sequence Pro-Arg-Ala in place of thesequence Thr-Arg-Ile of the activation site of native factor X. These factor X analogues can be used to obtain procoagulant medicinal products.

L'invention concerne des analogues du facteur X contenant la séquence Pro-Arg-Ala à clivage par la thrombine remplaçant la séquence Thr-Arg-Ile du site d'activation du facteur X d'origine. Ces analogues du facteur X peuvent être utilisés pour obtenir des produits médicinaux coagulants.

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