Thrombin derived peptides for smooth muscle relaxation

Details Thrombin derived peptides for smooth muscle relaxation Thrombin derived peptides for smooth muscle relaxation

A - Human Necessities

61

K

A61K 38/48 (2006.01) A61P 21/02 (2006.01)

Patent

CA 2722621

Agonists of a non-proteolytically activated thrombin receptor, and more particularly, thrombin peptide derivatives, can be used in methods to cause smooth muscle relaxation. Compositions comprising thrombin peptide derivatives can be administered to a subject with a disease or disorder that can be ameliorated by relaxation of smooth muscle. Such compositions can also be administered to a subject to facilitate medical, diagnostic or surgical procedures.

Des agonistes d'un récepteur de la thrombine non activé protéolythiquement, et plus particulièrement des dérivés peptidiques de la thrombine, peuvent être utilisés dans le cadre de méthodes de relaxation des muscles lisses. Des compositions renfermant des dérivés peptidiques de la thrombine peuvent être administrées à un sujet atteint d'une maladie ou de trouble pouvant être atténués par la relaxation de muscles lisses. On peut également administrer de telles compositions à un sujet afin de faciliter des actes médicaux, diagnostiques ou chirugicaux.

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