Thrombin inhibitors

Details Thrombin inhibitors Thrombin inhibitors

C - Chemistry, Metallurgy

07

K

C07K 5/08 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01) C07K 5/087 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2159834

4-substituted cyclohexylamine derivatives which are thrombin catalytic site inhibitors and which are useful as anticoagulants. These compounds show selectivity for thrombin over other trypsin-like enzymes and have oral bioavailabilty. They have formula (a) or (b), for exmple (c).

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